點擊化學 Alkynyl Palmitic Acid

更新時間：2024-08-07

簡要描述：

點擊化學 Alkynyl Palmitic Acid：
Alkynyl Palmitic Acid 是一種 PROTAC linker，屬于 alkyl chain 類?？捎糜诤铣?PROTAC 分子。Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PR

點擊化學 Alkynyl Palmitic Acid

炔基肉豆蔻酸可用于鑒定和表征翻譯后的肉豆蔻基化蛋白質炔基棕櫚酸（15-十六烷酸或棕櫚酸 (15-yne)）是一種修飾的棕櫚酸，帶有 ω-末端炔烴。炔基棕櫚酸通常用于使用強大的點擊化學識別和表征蛋白質的翻譯后 S-棕櫚酰化。.

Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry (see References).

結構式：

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Alkyne-PEG4-Acid	TA102-100	100 mg	$195	click chemistry tools
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Cy7 NHS Ester	1115-1	1 mg	$105	click chemistry tools
Click-&-Go™ Plus 405 Labeling Kit	1313	1kit	$219	click chemistry tools
Click-&-Go™ Plus 546 Labeling Kit	1316	1kit	$219	click chemistry tools
Click-&-Go™ Plus 647 Labeling Kit	1320	1kit	$219	click chemistry tools

參考文獻

1. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107.

2. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890.

3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res .

4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501.