Anti-Glutathione抗體D8 (ab19534)

中文背景介紹：

Glutathione是一種小肽，由三種氨基酸組成，存在于組織中，濃度高達(dá)一毫摩爾。它在cysteine的胺基和glutamic acid側(cè)鏈的羧基之間含有不尋常的肽鍵。Glutathione參與解毒，它與重金屬、溶劑和殺蟲(chóng)劑等毒素結(jié)合，并將其轉(zhuǎn)化為可以通過(guò)尿液或膽汁排泄的形式。它也是一種重要的抗氧化劑，有助于維持蛋白質(zhì)的-SH基團(tuán)的還原形式。慢性功能性Glutathione缺乏癥與葡萄糖6-磷酸脫氫酶缺乏癥、免疫紊亂、惡性腫瘤發(fā)病率增加有關(guān)，在HIV疾病的情況下，可能加速了疾病的發(fā)病機(jī)制。功能性Glutathione缺乏的急性表現(xiàn)可見(jiàn)于用過(guò)量APAP。這導(dǎo)致肝細(xì)胞中Glutathione的消耗，導(dǎo)致肝衰竭和死亡。

英文背景介紹：

Glutathione is a small peptide composed of three amino acids: cysteine, glutamic acid, and glycine and is present in tissues in concentrations as high as one millimolar. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. It is also an important antioxidant, helping to maintain the -SH groups of proteins in their reduced form. Chronic functional glutathione deficiency is associated with glucose 6-phosphate dehydrogenase deficiency, immune disorders, an increased incidence of malignancies, and in the case of HIV disease, probably accelerated pathogenesis of the disease. Acute manifestations of functional glutathione deficiency can be seen in those who have taken an overdosage of acetaminophen (paracetamol). This results in depletion of glutathione in the hepatocytes, leading to liver failure and death.

Virogen品牌101-A產(chǎn)品名稱(chēng)別名：

Glutathione antibody

GSH antibody

Oxidised glutathione antibody

Reduced glutathione antibody

Anti-Glutathione抗體[D8] (ab19534)實(shí)驗(yàn)圖片：

101-A staining Glutathione in cultured murine RAW 264.7 cells by Immunocytochemistry/ Immunofluorescence.
Cells were fixed in paraformaldehyde, permeabilized using 0.1% Triton-X100 in 2% BSA for 15 minutes, blocked with 2% BSA for 1 hour at 22°C and then incubated with 101-A at a 1/150 dilution for 16 hours at 4°C. The secondary used was an Alexa-Fluor 488 conjugated goat anti-mouse IgG (H+L) used at a 1/1000 dilution.

Anti-Glutathione抗體[D8] (ab19534)，靶點(diǎn)科技現(xiàn)貨，聯(lián)合Virogen廠家，常年現(xiàn)貨，隨時(shí)發(fā)貨。原裝正品，質(zhì)量保證。